Miho Shinohara is a care-free third-grader and an aspiring manga artist. One day, she encounters Mogu and Pigu - two lost fairies disguised as stuffed animals. In exchange for staying at her home until they find a way to return to their own world, the fairies give Miho a special sketch pad and pencil that enable her to magically create real objects from what she draws. With the pen, Miho can also transform into Lala, a beautiful teenage girl created from her manga art. As Lala, she is discovered by a talent agency, and so begins her adventures from an ordinary school girl to a model to an idol singer.

The Demon Lord Tasogare's castle is a dark and frightening place, filled to the brim with various monsters. Any soul unfortunate enough to be imprisoned here is sure to be terrified by the horrors within. However, the human princess Aurora Suya Rhys "Syalis" Kaymin is a different case. Rather indifferent to her situation, Syalis worries about one thing and one thing only—sleep. Ever since the demon lord kidnapped her from her kingdom, she has not had a single good night's rest.

Fifty years ago, horrific creatures dubbed as the "enemies of humanity" suddenly appeared around the world. To combat these threats, teenagers gifted with supernatural abilities called "Talents"—such as pyrokinesis and time travel—hone their powers at an academy on a secluded island.

Despite being bullied, scorned, and oppressed all of his life, a thirty-four-year-old shut-in still found the resolve to attempt something heroic—only for it to end in a tragic accident. But in a twist of fate, he awakens in another world as Rudeus Greyrat, starting life again as a baby born to two loving parents.